It is possible to connect the RS232 serial cable with a current Windows PC using a compatible RS232-USB adapter. I have a 'Belkin PDA Adaptor', which works well and has 64-bit drivers for Windows. I cannot guarantee all USB-RS232 chipsets will work. I have read that PsiWin prefers COM ports 1-4, and also needs to use the RTS / CTS signals, so any adapter must provide these.