I remember receiving a CF card prepped by a friend. I read it with my basic multi-purpose card reader (which works very well for micro SD cards) and coïncidence (or not): the data was destroyed at first access and the card became unreadable.
My friend told me that those all-purpose card readers were low quality for the compact flash format, and recommended a specific CF card reader. Not doing a lot of formats but at least reading and writing CF format properly.
The brand that he recommended is Hama (note: I'm not affiliated with Hama, but it's the only card reader I have successfully tested).
As you notice in the picture, there aren't 546 formats supported or any USB mug warmer. Just Compact flash and 2 others (that I never used). I've been using that device for a few months (with PFS3 and normal FFS) now and never had any issues, even with cheap CF cards.
I suppose that some other CF-specific card readers are as reliable. Just don't try cheap reader hardware on those cards. Invest in a specific reader.