As things look in 2022:
Do differentiate between opportunist malware threats (something scanning around for whatever it could use for a botnet/spam/malware hub) and Advanced Threat Actors(tm)/targeted attackers.
Do assess whether your home network is really just for your own use ... or if you are either running infrastructure others use (eg a self hosted server) and/or also using it for machines involved in your own or somebody's business (home office/mobile office!). Eg, if somebody has no reason to really try and attack you, they might have a reason to do so to your customer or your boss' customer.
Opportunist software would USUALLY not bother ... but you can't be sure someone is not trying to take advantage of the proliferation of badly secured legacy systems in businesses.
Advanced threat actor - big problem anyway, bigger problem if you have obsolete systems.
Be aware of threats like ZuoRAT, which can turn home/home office routers into attack bridgeheads.
If in doubt, it is sensible to at the minimum isolate your vintage/experimental systems on a different subnet behind a sub-router/sub-firewall (VLANs and a router-on-a-stick topology are not perfect but far, far better than nothing for that). This would foil simple opportunist scanners, simply scanning the subnet behind your home router, unless they expect that kind of setup: either that sub-router uses NAT which acts as a default no-ingress policy, or it uses a plain routed subnet which would take more scanning effort. This would complicate things for a targeted attacker, probably making their action more evident. This would make it much more easy to you to start monitoring things in case you have suspicion something is going on. This will allow you to react by restricting access with firewall rules. This will keep obsolete and probably insecure protocols (eg AFP, SMBv1, pre-TCP/IP stuff) off your main network's broadcast domain. Also consider adding a separate, well secured and monitored, wifi access point into that network if you work with legacy/experimental wifi enabled devices.