The Gotek floppy emulators are really popular in the retro scene. I have one modified (firmware update) to work with my Amiga 500.
Can one be made to work with any of the classic line of Macintosh computers?
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The Gotek floppy emulator appears to only support two firmwares: Cortex (Amiga only) and HcX (Amiga, Atari, Amstrad, and Spectrum).
There is another floppy emulator, the BMOW Floppy Emu, which supports classic Macintosh hardware (Macintosh, Apple II, and Lisa Floppy/Hard Disk). There are firmware downloads on the linked page.