If we are looking back to home computers, maybe the Q60 was the last real "Home computer clone", a Sinclair QL on steroids using a Motorola 68060 CPU in a PC case using ISA slots. It was first available 1999. I don't know how long exactly it was sold, but I seem to recall well into 2005.
Its home page is still up (although it is named after its predecessor, the Q40 that used a 68040 CPU) in case you want to learn something about this really rare "home computer".
Apart from running an extended version of QDOS, the QL's native operating system, the Q60 could also run its predecessor, SMSQ/ and 68k Linux.
I do, however, think that the classic home computer has never died - Still today, it was proven to be possible to get well over 700kGBP funding for a project like the Spectrum Next on Kickstarter - This will, once released, obviously be the next "last Home Computer".
Some elaborations on the Sinclair QL history as comments (somehow) seem to ask for them:
After the demise of the Sinclair QL which wasn't going to be continued by Amstrad starting from the Sinclair buy 1986, QL owners were kind of orphaned from any backing by suppliers.
Some of the peripherals suppliers jumped in and continued to produce first expansion boards, then, after the original supply of new computers made by Sinclair and cheaply thrown onto the market by Amstrad dried out, continually moved towards supplying complete QL compatible computers. Some examples (in roughly chronological order, and only the most important developments):
- Miracle Systems Gold/SuperGold Card: Produced during the Sinclair/Amstrad transition phase - A plug-in card to replace most of the original QL except video and peripherals. Had a 68000 CPU and 2MB of memory (GoldCard) or a 68020 and 4MB RAM (Super GoldCard). Both copied and runtime-patched the original QL ROM into fast RAM, mainly for speed and circumventing any copyright issues (Amstrad initially threatened to sue anyone who would copy Sinclair intellectual property)
- Sandy QXT-640 Was a complete computer built from original QL motherboards and Sandy components into a new case.
- CST Thor A QL compatible range of computers, initially only an original QL built into a new case, then expanded with a 68020 CPU (but retaining the 8-bit data-bus), later the Thor 16 that was a completely new development based on the 68000. Last produced in Denmark by Dansoft, their biggest customer was Ritzaus, a news agency. Used Argos, a (claimed) re-engineering of QDOS for copyright issues, how much of it was just stolen and how much was actually CST property was never really worked out.
- Miracle QXL card - A PC-ISA co-processor card that had a 68040 and 4/8MB of memory as the core and used PC peripherals (video, disk, keyboards, other peripherals). This used SMSQ/E, a complete re-development (and major enhancement) of QDOS by the original QDOS developers.
- Q40/Q60 a described above
Today, QLs live on in the form of quite a number of emulators, the MiST FPGA platform, and a number of smaller community-based projects supplying hardware. There is also a number of forums that host the still active user community.