The DEC Rainbow (1982) was built with two CPUs on the motherboard. One was an 8088 and the other was a Z80. It could run 8 bit CPM, 16 bit CPM, or MS-DOS. When running MS-DOS, the Z808080 was used as an I/O processor for disk access.
This doesn't quite fit your criterion, because only one of the two CPUs was x86, and because there was no OS that allowed user tasks to run concurrently on the two CPUs.