The Gotek floppy emulators are really popular in the retro scene. I have one modified (firmware update) to work with my Amiga 500.
Can one be made to work with any of the classic line of Macintosh computers?
The Gotek floppy emulator appears to only support two firmwares: Cortex (Amiga only) and HcX (Amiga, Atari, Amstrad, and Spectrum).
There is another floppy emulator, the BMOW Floppy Emu, which supports classic Macintosh hardware (Macintosh, Apple II, and Lisa Floppy/Hard Disk). There are firmware downloads on the linked page.
Possibly... Six years since your post, things have moved on a little. Work seems to be underway on the FlashFloppy firmware for the Gotek.
See Apple II and/or classic Macintosh support #733 and this question, Which wires need to be changed to use a Gotek floppy emulator on an Apple Mac?.